Best Supplements for Weight Loss To Burn Fat & Boost Metabolism in 2025
As you age, shedding excess fat and maintaining a lean physique can become increasingly challenging. Slower metabolism, hormonal shifts, and lifestyle changes often make it harder to stay in shape, even with diet and exercise.
If you’ve noticed stubborn belly fat creeping in or feel like your energy just isn’t what it used to be, the right support can make all the difference. That’s where the best supplements for weight loss come in.
From boosting metabolism to enhancing fat burning and promoting lean muscle growth, these supplements, such as PhenQ and others we’ll review shortly, can help you get back on track and feel confident in your body again.
The Best Supplements for Weight Loss: Quick Overview
- PhenQ – Our #1 pick of the best supplements for weight loss
- KetoCharge – Best weight loss supplement for keto dieters
- Phen24 – Best supplement for weight loss around the clock
- PrimeShred – Best for weight loss and lean muscle growth
- CalmLean – Best non-stimulant weight loss supplement
- Trimtone – Best weight loss supplement for women
- Instant Knockout Cut – Best energy-boosting weight loss supplement
- Zotrim – Best herbal appetite suppressant
- Transparent Labs Body Recomp – Best for body recomposition
Detailed Reviews of the Best Supplements for Weight Loss
Ready to find the right supplement for your weight loss journey? Let’s take a closer look at each option on our list to help you make an informed decision.
1. PhenQ – Overall, Best Supplement for Weight Loss
Pros
- Recommended by over 700 clinicians on FrontrowMD
- Try for 60 days risk-free
- Subscribers get 15% off
- Free fitness guide with every order
Cons
- Free shipping starts at $79.99
Overview
Using 6 powerful ingredients led by a-Lacys Reset, which includes both alpha-lipoic acid and L-cysteine, PhenQ helps you reach your ideal weight in five different ways. These include reducing cravings, burning fat, boosting energy, balancing mood, and stopping fat growth, so that belly fat doesn’t stand a chance.
Dosage
- 1 capsule with breakfast and 1 with lunch
- Contains caffeine, so don’t take it after 3 pm
Pricing
- 1-month supply: $69.99
- 3-month supply: $139.99
- 5-month supply: $209.99
User Reviews
One anonymous user on Trustpilot said they love PhenQ after losing 23 pounds in just 3 months. Another user said PhenQ didn’t work for them, but customer service refunded their money, so everything worked out [1] [2].
If you’re ready to revisit leaner times, then trust PhenQ to get you there. It is one of the best natural supplements for weight loss for most people because it covers the basics.
>>Check the best deals for PhenQ on the official website
2. KetoCharge – Best Weight Loss Supplement for Keto Dieters
Pros
- Suitable companion for a keto diet
- Helps manage keto flu
- Bigger savings on bulk orders
- 60-day money-back guarantee
Cons
- Not a comprehensive weight loss formula
Overview
KetoCharge provides the edge you need, making it easier to get into ketosis, avoid keto flu, and survive occasional cheats. It works by fast-tracking ketosis for carb-free energy, plus the amino acid glycine helps improve mood.
Dosage
- 2 capsules with 8oz of water every morning on an empty stomach
Pricing
- 1-month supply: $59.99
- 3-month supply: $119.99
- 5-month supply: $179.99
User Reviews
Elizabeth on Trustpilot said KetoCharge was a game changer, helping digestion and providing more energy. But Barn was not happy at all after ordering and then being told by customer service that the item was out of stock [3] [4].
As one of the best keto supplements for weight loss, KetoCharge offers all the key ingredients you need for your fitness journey. So, if your ketosis is dragging on, KetoCharge can get you over the finish line.
>>Buy KetoCharge from the official website
3. Phen24 – Best Supplements for Weight Loss Around the Clock
Pros
- Dual fat-burning formula
- 60-day money-back guarantee
- 100% vegetarian and vegan friendly
- Suitable for reducing late-night cravings
Cons
- The day formula might be overstimulating
Overview
Phen24 is the diet supplement that works 24/7 to banish hunger, burn fat, and furnish energy all day, while also crushing cravings, burning fat, and calming you at night. If cravings usually get the best you in the wee hours, Phen24 will keep you sleeping and burning fat instead.
Dosage
- Day formula: 2 capsules daily at breakfast
- Night formula: 4 capsules at night before dinner
Pricing
- 1-month supply: $69.99
- 3-month supply: $139.99
- 5-month supply: $209.99
User Reviews
The official website only includes a few positive reviews. Check Quora or Reddit for more balanced customer feedback.
The song says “rust never sleeps,” and neither does fat burning with Phen24. It is among the best amino acid supplements for weight loss you can try.
>>Check the current prices for Phen24
4. PrimeShred – Best for Weight Loss and Muscle Gain
Pros
- 100-day refund policy
- Subscribers get 20% off
- Vegan friendly
- Manufactured in an FDA-approved, GMP-certified facility
Cons
- $15 fee on all returns
Overview
PrimeShred has no sales pitch, just facts. Like their 100-day guarantee. If you’re not shredded after 50 days of busting it, just return PrimeShred for a refund.
They say their formula contains science-backed ingredients that burn fat, build lean muscle, and keep your mood level. Just look in the mirror. If you’re not cut to order, they’ll cut you a check. It’s that simple.
Dosage
- 3 capsules 20 minutes before breakfast on training and non-training days
Pricing
- 1-month supply: $59.99 or $47.99 when you subscribe
User Reviews
On Trustpilot, Kevin vouched for PrimeShred as an amazing product. He emphasized that with hard work, the supplement can address your weight problems. Andy also loved PrimeShred, but warned about exorbitant import fees if you’re in the U.K. [5] [6].
If you’re looking for the best supplements for weight loss and muscle gain, you can’t go wrong with PrimeShred. It is the top option for a pure shred with no proprietary blends.
>>Buy PrimeShred from the official website
5. CalmLean – Best Pills for Weight Loss Without Stimulants
Pros
- Suitable for those sensitive to stimulants
- 67-day refund policy
- 100% stimulant-free
- $10 off when you subscribe
Cons
- Free shipping starts at $99
Overview
If you’re up for a challenge, CalmLean claims you can lose weight without stimulants. They also guarantee your money back if you don’t lose 1 pound per week with their powerful thermogenic recipe.
Dosage
- 2 capsules daily with water
Pricing
- 1-month supply: $59 or $49 for subscribers
- 3-month supply: $169
- 6-month supply: $319
User Reviews
One Amazon user felt “good” and had a “great day” after taking it, unsure if the effects were mental or product-driven, but will continue to use it. Conversely, another saw no significant difference, noting individual responses can vary [7] [8].
CalmLean is among the best products for weight loss you can try if you’re sensitive to stimulants. With a money-back guarantee promising at least one pound of weight loss per week, CalmLean truly offers a cool deal.
>>Check the best price for CalmLean
6. Trimtone – Best for Women
Pros
- Low stimulant formula designed for women
- Simple one-a-day dosage
- Try risk-free for 100 days
- Subscribe and get 20% off plus freebies
Cons
- Not suitable for vegetarians
Overview
If your body goals seem unreachable, Trimtone is your ticket to empowerment. Its five simple, scientifically backed ingredients of caffeine, green coffee and tea, grains of paradise, and glucomannan, combined with diet and exercise, will lighten even the heaviest mood.
Dosage
- 1 capsule daily before breakfast
Pricing
- 1-month supply: $39.99 or $31.99 for subscribers
User Reviews
In her Amazon review, Denise lauded Trimtone for effectively curbing her appetite without side effects. However, O’Neal saw minimal difference and wasn’t “super impressed” [9] [10].
If you’re sick of waiting for the arrival of weight loss supplement promises, Trimtone aims to please, the healthy way. Plus, its low stimulant formulation ensures you get effective fat burning without the jitters.
7. Instant Knockout Cut – Top Energy-Boosting Weight Loss Supplement
Pros
- Free workout and diet guide with bulk orders
- Subscribe and receive 10% off the regular price
- Formulated for bodybuilders
- Vegetarian and vegan friendly
Cons
- Limited 30-day return policy
Overview
What began as a supplement for MMA athletes is now available to help you with your weight loss battles. Providing a smooth combination of vitamins, amino acids, natural stimulants, and pepper extracts, this is a flurry that will boost energy, burn fat, and keep you focused.
Dosage
- 4 capsules daily: on waking, between breakfast and lunch, an hour after lunch, and an hour before dinner
Pricing
- 1-month supply: $65
- 3-month supply: $130
- 5-month supply: $195
User Reviews
Dmitriy said in his Trustpilot review that he has been using Instant Knockout Cut for 2 months, and all he has to say is that it was “awesome!” Conversely, Ginny didn’t fare as well; the supplement made them ill, but customer service was there with a refund [11] [12].
If losing weight has been a losing battle, Instant Knockout Cut is among the best supplements for weight loss to fuel your comeback. It includes the right ingredients to jumpstart fat burning and fuel your workouts.
>>Explore more Instant Knockout Cut benefits here
8. Zotrim – Best Herbal Appetite Suppressant
Pros
- Backed by 5 clinical trials and 10 expert-approved papers
- 100-day money-back guarantee
- Compact, portable container
- Save up to 40% on your third order when you subscribe
Cons
- Not for those sensitive to caffeine
Overview
Containing yerba mate to control appetite and induce fullness, guarana for boosting metabolism and energy, and damiana for calm and well-being, Zotrim is an all-natural appetite suppressant. Plus, there are added B vitamins for energy and caffeine to wake up your metabolism.
Dosage
- 2 or 3 tablets before each meal
Pricing
- 1-month supply: $59.99 or $47.99 for subscribers
User Reviews
Aside from the positive reviews on the official website, you might need to check Quora or Reddit for balanced user feedback.
Zotrim is among the best products for weight loss if you need an all-natural way to suppress your appetite that can be as flexible as your lifestyle.
9. Transparent Labs Body Recomp – Best for Body Recomposition
Pros
- No artificial sweeteners, coloring, or preservatives
- Gluten-free and non-GMO
- Easy access to third-party test results
- Offers a stimulant-free alternative
Cons
- May cause jitters if taken within five hours of bedtime
Overview
With clinically proven ingredients like ForsLean, Capsimax, green tea, caffeine, BioPerine, and L-theanine, Body Recomp helps to enhance metabolism, focus cognitive abilities, manage cravings, and even out your mood.
Dosage
- 2 capsules twice daily before meals
Pricing
- 1-month supply: $54.99 or $49.99 for subscribers
User Reviews
Jacob said on the official site that he lost 15 lbs in 8 weeks on Body Recomp after also changing their diet and doing mild cardio. Celina said Body Recomp sure suppresses her appetite, but she’s not a fan of the nausea [13].
If other vitamins for weight loss have given you the jitters, try Body Recomp by Transparent Labs with calming L-theanine. Or just get the stimulant-free option!
>>Get Transparent Labs Body Recomp from the official site
How To Choose the Right Weight Loss Supplement
Choosing the right supplement can feel overwhelming, especially with so many options out there. But by taking a smart, step-by-step approach, you can find something that truly supports your health goals.
Set Realistic Goals
Don’t let the perfect be the enemy of the good. Set realistic goals. A target as simple as 1 pound a week is something to build on.
Assess Your Lifestyle and Needs
Start by examining your diet; are you consuming enough essential nutrients? Identify foods contributing to weight gain and begin eliminating them.
For instance, consider whether a magnesium deficiency might be impacting your health, as many people don’t get enough from sources like leafy greens or dairy products. If so, magnesium supplements could be a beneficial addition to your daily regimen.
Make One Change at a Time
All journeys begin with a single step. Look to change a thing each day, and you’ll be surprised how far you’ve come in a month.
Track Results and Adjust
Tracking your progress reminds you how far you’ve come. Each goal attained organically creates the next step. Also, be willing to adjust whatever isn’t working.
>>Check the best deals for PhenQ on the official website
Factors That Influence the Effectiveness of Weight Loss Supplements
Many things can affect how well a supplement works for your body. It’s like a puzzle where all the pieces, like the ones below, need to fit for the best results.
Metabolism
Metabolism is the speed your body processes nutrients. If it’s slow, you may need fewer calories, and any excess could quickly become fat.
Age and Gender
Age and sex determine how you process nutrients and what type of supplements work best for you. For instance, older adults may need more or different nutrients than someone younger.
Lifestyle Habits
A healthy, balanced diet helps nutrient absorption, and regular exercise boosts your metabolism to accentuate any benefits a diet supplement has to offer.
Gut Health
Your digestive health (or lack thereof) directly impacts how you metabolize nutrients, and what type of supplements will work best for you. We recommend looking for the best supplements for gut health and weight loss.
Pre-existing Conditions
Pre-existing conditions can significantly impact how well weight loss supplements work. For example, someone with fatty liver disease might find their body processes ingredients differently, potentially reducing effectiveness or even causing issues with certain supplements like high-dose stimulants.
>>Check the best deals for PhenQ on the official website
Types of Weight Loss Supplements
Understanding how the different kinds of best supplements for weight loss work can help you pick the right one for you.
Appetite Suppressants
These supplements affect how you experience hunger. They can make you feel less hungry or fuller after eating less, so you won’t consume as many calories.
Fat Burners and Thermogenics
Fat burners and thermogenic supplements amp up your metabolism to burn more fat for energy instead of carrying it as excess weight.
Fat Blockers and Carb Inhibitors
Fat blockers prevent the body from absorbing dietary fat, while carb inhibitors do the same with carbohydrates to promote weight loss. However, both can lead to side effects such as abdominal or digestive discomfort, and in some cases, may even influence blood pressure.
Metabolism Boosters
These supplements accelerate metabolism to burn calories and fat faster. Some common metabolism boosters are caffeine and green tea.
Digestion Aids
These supplements improve nutrient absorption, so less food is desired. Some also claim to bind with dietary fat to prevent its absorption during digestion.
Key Ingredients in Top Weight Loss Supplements
Let’s break down some of the most common and well-researched ones you’ll find in the best pills for weight loss.
Green Tea Extract
Green tea is a source of energy and is believed to contain compounds that aid in metabolism and fat oxidation.
Glucomannan
Glucomannan is a dietary fiber used in weight loss supplements for its absorbency and ability to expand in the stomach to promote a feeling of fullness. This expansion occurs without the need for digestive enzymes, as it isn’t broken down in the same way other macronutrients are.
Conjugated Linoleic Acid (CLA)
This is a fatty acid believed to reduce body fat and increase lean muscle mass. Similarly, fish oil, rich in beneficial fatty acids, is also commonly explored for its potential role in body composition and overall health.
Berberine
This is a compound found in various plants like barberry and goldenseal and is believed to enhance the metabolism of fat and reduce appetite.
Probiotics
Studies on the use of probiotics in weight loss suggest that probiotics from the Bifidobacterium and Lactobacillus families can reduce body fat when combined with exercise. For this reason, they are the best supplements for bloating and weight loss.
5-HTP
5-Hydroxytryptophan helps increase serotonin levels, which may help reduce food intake and induce feelings of fullness.
L-Carnitine
This supplement acts as a transporter for moving fat through the cell mitochondria so it can be burned for energy and help reduce weight.
Fiber Supplements
Fibers like psyllium husk absorb water, slowing digestion in the intestines. This not only promotes feelings of fullness, helping to reduce overeating, but can also help regulate blood glucose levels.
Vitamin D
Since obese individuals often have low vitamin D levels, it is believed that increasing vitamin D can lead to fat loss.
Chromium Picolinate
Chromium picolinate’s role in insulin function assists how the body processes carbs, fats, and proteins, and may also help to reduce appetite and cravings. This makes it a useful addition to a diet, perhaps even alongside a protein powder or whey protein shake for comprehensive nutritional support.
Recommended Dietary Allowance
This table outlines key recommended dietary allowances (RDAs) for adults, focusing on nutrients vital for energy, metabolism, and overall health that can support your weight loss efforts.
| Nutrient | Adult Female (19-50 yrs) | Adult Male (19-50 yrs) |
| Protein | ~46 g | ~56 g |
| Fiber | 21-25 g | 30-38 g |
| Vitamin D | 15 mcg | 15 mcg |
| Calcium | 1,000 mg | 1,000 mg |
| Magnesium | 310-320 mg | 400-420 mg |
| Zinc | 8 mg | 11 mg |
| Iron | 18 mg (pre-menopause) | 8 mg |
| Water | 2.7 liters | 3.7 liters |
Expert Tips for Safe & Effective Use of Weight Loss Supplements
To maximize supplement benefits and safety, follow expert advice. Your dosage, timing, and lifestyle—including your body mass index—are crucial, not just taking the pill itself. Here are simple tips to guide you.
Timing and Dosage Strategies
Always follow the manufacturer’s guidelines. Never exceed the recommended dosage to avoid side effects. Many supplements contain stimulants, like caffeine, so try not to take them too late.
Importance of Hydration and Diet
Since some ingredients like caffeine act as a diuretic, staying hydrated is important when taking weight loss supplements. A healthy diet is also important to maintain the proper nutrient levels.
When To Cycle or Pause Supplementation
Cycling or pausing supplements is sometimes necessary to prevent becoming accustomed to any stimulants they contain, or to prevent the toxic buildup of fat-soluble nutrients like vitamin A.
Signs a Supplement May Not Be Working for You
Some signs a supplement isn’t working could be no noticeable improvements over time, adverse reactions like constant nausea, or poor absorption (gut issues can be an indication).
FAQs
These are some questions customers have been asking involving the best supplements for weight loss.
Do Weight Loss Supplements Actually Work?
Some individual ingredients, like caffeine or green tea extract, show effects on weight loss in studies. However, the scientific evidence for the effectiveness of multi-ingredient blends is often limited and inconclusive [14].
Are Natural Supplements Better for Weight Loss Than Synthetic Ones?
It’s more nuanced than just natural vs synthetic. Natural supplements may offer a wider range of nutrients and fewer side effects, while synthetic options or weight loss medications offer more precise doses and work faster.
Which Weight Loss Supplements Are Safest To Use?
When taken as directed, some natural weight loss supplements like green tea extract or glucomannan are considered safer than others due to their lack of side effects.
What Ingredients Should I Look for in the Best Weight Loss Supplements?
Some of the safest weight loss supplements to take are natural substances like green tea extract, natural fiber, and different vitamins and minerals like vitamin D or chromium.
Can Supplements Help Burn Belly Fat Specifically?
Supplements generally cannot specifically burn belly fat. Science shows “spot reduction” is a myth; fat is lost from your entire body, not just targeted areas. Effective belly fat reduction requires a consistent caloric deficit through diet and full-body exercise.
Best Supplements for Weight Loss: Conclusion
It is important to understand that even the best supplements for weight loss are only one factor in what can be a challenging and complicated equation.
Besides taking a weight loss supplement, like PhenQ, it’s also important to have a healthy diet and regular exercise schedule to maximize your body’s fat-burning capabilities.
It is also critical to speak with your doctor or any healthcare professional before embarking on a weight loss program.